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Which Screening Is Used To Test For Diabetes


When To Screen For Type 2 Diabetes

Early Diabetes Screening Test
  • Screen every 3 years in individuals 40 years of age
  • Screen every 3 years in individuals at high risk according to a risk calculator
  • Screen earlier and/or more frequently in people with additional risk factors for diabetes
  • Screen earlier and/or more frequently in people at very high risk according to a risk calculator

Conditions that lead to misleading A1C include: hemoglobinopathies, hemolytic anemia, iron deficiency, severe renal or liver disease. Link to Table 1, Monitoring for Glycemic Control.

  • Validated Assay: A1C must be measured using a validated assay standardized to the National Glycohemoglobin Standardization Program-Diabetes Control and Complications Trial reference.
  • Ethnicity: Studies indicate that African Americans, American Indians, Hispanics and Asians have A1C values that are up to 0.4% higher than those of Caucasian patients at similar levels of glycemia . Research is required to determine if A1C levels differ in African Canadians or Canadian First Nations.
  • Age: A1C values are affected by age, rising by up to 0.1% per decade of life . More studies may help to determine if age- or ethnic-specific adjusted A1C thresholds are required for diabetes diagnosis.
  • Special Populations: A1C is not recommended for diagnostic purposes in children, adolescents, pregnant women or those with suspected type 1 diabetes.
  • Urine Testing For Diabetes

    Urine tests arent always used to diagnose diabetes. Doctors often use them if they think you may have type 1 diabetes. The body produces ketone bodies when fat tissue is used for energy instead of blood sugar. Laboratories can test urine for these ketone bodies.

    If ketone bodies are present in moderate to large amounts in the urine, this could indicate your body is not making enough insulin.

    What Happens During A Diabetes Test

    There are several ways to screen for and diagnose diabetes. Most tests involve measuring glucose levels in the blood.


    To get a blood sample, a health care professional will take a blood sample from a vein in your arm, using a small needle. After the needle is inserted, a small amount of blood will be collected into a test tube or vial. You may feel a little sting when the needle goes in or out. This usually takes less than five minutes.

    The different types of glucose blood tests include:

    • Blood glucose test, also known as fasting blood glucose. Before the test, you will need to fast for eight hours before the test. This test is often used as a screening test for diabetes. It may be repeated to confirm a diagnosis.
    • Oral glucose tolerance test . This test also requires fasting before the test. When you arrive for your test, a blood sample will be taken. You will then drink a sugary liquid that contains glucose. About two hours later, another blood sample will be taken.
    • Random blood sugar. This test can be taken at any time. No fasting is required.
    • Hemoglobin A1c . This test measures the average amount of glucose attached to hemoglobin over the past 3 months. Hemoglobin is the part of your red blood cells that carries oxygen from your lungs to the rest of your body. No fasting is required for this test.

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    Who Should Get Tested For Diabetes

    The American Diabetes Association recommends getting screened for diabetes every 3 years starting at age 45. If you are at a high risk of diabetes, your doctor may advise you to get tested sooner or more frequently. Risk factors include:

    Early warning signs may not be apparent for many years after the disease has begun. If you are at high risk of diabetes, talk to your doctor to start treatment right away.


    General Recommendations For The Evaluation Of High

    Test for diabetes

    Based on the lack of data from prospective studies on the benefits of screening and the relatively low cost-effectiveness of screening suggested by existing studies, the decision to test for diabetes should ultimately be based on clinical judgment and patient preference.

    On the basis of expert opinion, evaluation of the general population should be considered by their health care provider at 3-year intervals beginning at age 45. The rationale for this interval is that false negatives will be repeated before substantial time elapses, and there is little likelihood of an individual developing any of the complications of diabetes to a significant degree within 3 years of a negative screening test result. Testing should be considered at a younger age or be carried out more frequently in individuals with one or more of the risk factors shown in .

    Patients presenting to health care providers with symptoms of marked hyperglycemia, including polyuria, polydipsia, weight loss and blurred vision, should receive diagnostic testing for diabetes, as should those with potential complications of diabetes or with any other clinical presentation in which diabetes is included in the differential diagnosis. Such diagnostic testing, however, does not constitute screening.

    • Have a family history of type 2 diabetes in first- and second-degree relatives

    • Belong to a certain race/ethnic group

    • Have signs of insulin resistance or conditions associated with insulin resistance .

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    Quick Answers For Clinicians

    Because hemoglobin A1c testing measures the average amount of glucose attached to hemoglobin in red blood cells over approximately 3 months, conditions that affect RBC turnover can skew results. These conditions include hemolytic anemia, glucose-6-phosphate dehydrogenase deficiency, recent blood transfusions, drugs that stimulate erythropoiesis, end-stage kidney disease, and pregnancy. Hemoglobin variants may also interfere with A1c results A1c assays without interference, plasma blood glucose criteria, fructosamine, or 1,5-anhydroglucitol should be used in individuals with hemoglobin variants. For more information on hemoglobin variants, see the Hemoglobinopathies topic.


    Once a diagnosis of type 1 diabetes mellitus has been made, autoantibody testing can be helpful in establishing an autoimmune etiology. Autoantibody testing may also help to exclude the diagnosis of T1DM in adults without traditional risk factors for type 2 diabetes mellitus and/or younger age. The American Diabetes Association also recommends that pediatric patients who are overweight or obese and suspected of having T2DM have autoantibody testing performed to exclude the possibility of autoimmune T1DM.

    Should Hba1c Be Accepted As A Diagnostic Criterion For Diabetes

    After careful discussion of the above issues and others, the panel determined that the HbA1c 6.5% or greater should be accepted as a criterion for diagnosing diabetes . The rationale for this cutoff is presented below, although it is recognized that precise cut points are a matter of judgment and are inevitably arbitrary. A single elevated HbA1c would not suffice to establish the diagnosis, but would require a second test. If the first test HbA1c is unequivocally elevated , this could be confirmed with a second HbA1c because interference with the assay is unlikely if the first A1c is 6.56.9, it should be confirmed with a plasma glucose-specific test . This should provide adequate protection against misinterpreting a HbA1c that is slightly elevated due to nonglycemic factors. HbA1c would not be considered valid in the setting of anemia or known confounders. These caveats are no more burdensome than the current requirement that PG criteria be repeated on another day and be done with the person in a stable clinical state. Indeed, HbA1c and a PG could be done on the same day, establishing the diagnosis without repeat testing.

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    Harms Of Screening And Treatment

    Some of the trials reporting on the benefits of screening and interventions for prediabetes and type 2 diabetes also reported harms. Overall, the ADDITION-Cambridge and Ely trials, and a pilot study of ADDITION-Cambridge,28,29,44-46 did not find clinically significant differences between screening and control groups in measures of anxiety, depression, worry, or self-reported health. However, the results suggest possible short-term increases in anxiety among persons screened and diagnosed with diabetes compared with those screened and not diagnosed with diabetes.

    Harms of interventions for screen-detected or recently diagnosed type 2 diabetes were sparsely reported and, when reported, were rare and not significantly different between intervention and control groups across trials.2,23 The UKPDS trial reported 1 patient of 911 in the intervention group receiving insulin who died from hypoglycemia, and serious hypoglycemic events requiring medical attention in 6 of 619 participants receiving chlorpropamide, 9 of 615 receiving glibenclamide, 16 of 911 receiving insulin, and 6 of 896 in the conventional care group.36


    Capillary Blood A1c Testing

    Diabetes Symptoms & Treatments : Testing for Diabetes

    Capillary blood A1C measurement, also called point-of-care A1C testing, is becoming a popular method for office-based monitoring of glucose control. In a study of 597 subjects , rapid POC A1C measurement resulted in more frequent intensification of the diabetes regimen when A1C was 7%. In the same study, in the 275 patients with two follow-up visits, A1C fell significantly in the rapid-test group but not in the routine group .

    In a study of correlation between a specific POC A1C method and a standardized laboratory value from the Diabetes Control and Complications Trial, the two were found to be similar, although the DCA 2000 measured slightly higher values. Newer POC instruments are now available, and although more studies are needed to confirm reliability with standardized assays, the POC method seems promising for convenient monitoring of glucose control.

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    Types Of Blood Tests Used For Diabetes Diagnosis

    Diabetes is a very common disease or health condition. Blood glucose level is very high here. Diabetes cannot make any rapid problems in your body. But being diabetic for a long time is dangerous. This may lead to serious health problems. Studies stated that 34.2 million people of all ages had diabetes almost 10.5 percent of the American population.

    Who Should Be Screened For Diabetes

    According to the American Diabetes Association, all patients should be screened for diabetes at three-year intervals beginning at age 45, especially people who are overweight or obese. If multiple risk factors are present, screening should be done at an earlier age and more frequently. The U.S. Preventive Services Task Force recommends that adults with high blood pressure or high cholesterol be screened for type 2 diabetes in an effort to reduce cardiovascular disease.


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    Overview Of Available Tests

    Proposed tests for diabetes screening are numerous and vary from history- and anthropometric-based questionnaires to proteomics-based risk assessment.- Although some of these tests might prove to be useful, the current preferred tests are limited to two groups: serum glucosebased tests and glycated proteins. Serum glucosebased tests include fasting plasma glucose , random plasma glucose , and the oral glucose tolerance test . The most well-studied and useful glycated protein is A1C.

    The 1997 ADA recommendations for diagnosis of diabetes focus on the FPG, whereas the World Health Organization focuses on the OGTT. However, practicing physicians frequently employ other measures in addition to those recommended, including urinary glucose, RPG, and A1C. In one survey of primary care physicians and mid-level providers, 89% of providers reported using FPG for screening in some cases, 58% used RPG, and 42% used A1C. For confirmation of a diabetes diagnosis, 80% used A1C, and 64% used FPG. Only 7% of providers reported that they regularly use the OGTT to diagnose impaired glucose tolerance . A survey conducted by Ealovega et al. found that 95% of opportunistic screening was done by RPG, 3% by FPG, 2% by A1C, and < 1% by OGTT.

    What Is Diabetesand Types Of Blood Sugar Tests

    Diabetes test

    The main source of blood sugar is the food that we eat. The glucose collected from our food is released into the bloodstream and used for energy. When there is a high blood sugar our body asks the pancreas to produce insulin which helps in using the blood sugar for energy production.

    Diabetes disturbs the process. As a result of diabetes, disorder body will stop producing enough insulin or resist using insulin. The shortage of insulin or the bodys resistance in using causes too much blood sugar to remain in the bloodstream. This may lead to serious health problems such as kidney disorders, heart diseases, and even vision loss.


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    The Glucose Tolerance Test

    This test is used to determine your body’s response to sugar . A glucose tolerance test is used to screen for type 2 diabetes and very often it is used to diagnose gestational diabetes. Generally speaking, your doctor will likely have a screening test during your second trimester – between 24 and 28 weeks of pregnancy.

    • Be sure to ask your health care providers who will arrange your test and who will share the results with you.

    • Fast for eight hours before the test. After the lab takes a blood sample, you will be given a sugary drink. Two hours later, you will have another blood test.

    NOTE: If your results are abnormal, arrange to discuss this further with your health care provider. If your results are normal you will need to be tested before planning another pregnancy or every 3 years or more often depending on risk factors.

    Capillary Blood Glucose Meters

    Capillary glucose measurement is a popular method for determination of point glucose measurements at the time of office visits and is recommended for self-monitoring by patients. However, because of meter imprecision and the substantial differences among meters, their usefulness in screening and diagnosis is limited. Any glucose abnormalities detected with a capillary glucose meter should be confirmed with laboratory testing.

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    Implications For Policy And Practice

    This study evaluated the performance of diabetes screening of Iran using a population-based sampling method.

    All procedures, instruments, and personnel used in this study were similar to those used by the national screening program making the results more representative and applicable.

    New cut points are provided to increase the performance of the screening tests.

    Fasting Blood Sugar Test

    Diagnosis of type 2 diabetes

    Fasting blood sugar tests involves having your blood drawn after youve fasted overnight, which usually means not eating for 8 to 12 hours:

    • Results of less than 100 mg/dL are normal.
    • Results between 100 and 125 mg/dL indicate prediabetes.
    • Results equal to or greater than 126 mg/dL after two tests indicate diabetes.

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    What Is A Diabetes Screening

    A diabetes screening is a test used to determine if you have diabetes. Diabetes is a serious medical condition where the body does not produce enough insulin to effectively convert the food you eat into energy.

    Approximately 1.4 million people are diagnosed with diabetes each year and as many as 30 percent of people who have diabetes do not know they have the condition until they experience serious complications. If left untreated, diabetes can increase your risk of developing heart disease, stroke, coronary artery disease and peripheral vascular disease.

    Early screening can help you manage or reverse your condition.

    What can you expect during a diabetes screening?

    Who should have a diabetes screening?

    • Age Type 2 diabetes is more prevalent in older people
    • Race African Americans, Hispanics, American Indians and Asian Americans are more likely to develop diabetes
    • Family history if a first-degree relative has diabetes, you are more likely to develop it as well
    • Overweight or obese individuals people who are overweight or obese are at higher risk for developing diabetes
    • Sedative lifestyle people who live an inactive lifestyle are more likely to develop diabetes

    How often should you have a diabetes screening?

    What Are Home Diabetes Tests

    Home diabetes tests usually provide everything you need to test A1C, also called HbA1c. According to the American Diabetes Association, this metric shows your average blood glucose levels over the previous 2 to 3 months, rather than standard glucose testing that only provides a snapshot of that moment.

    Because A1C tests provide an overall picture of your blood sugar levels, theyre a good indicator of how your body manages glucose.


    At-home diabetes tests allow you to take a blood sample at home and mail it to a laboratory for analysis. Then, after a few days, youll receive your results through a phone app, email, or on a secure web platform.

    If there are any atypical results, follow up with your primary care physician to discuss the next steps.

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    Should We Screen For Prediabetes And Undiagnosed Type 2 Diabetes

    Prediabetes and type 2 diabetes represent a pathophysiological and clinical continuum.

    Table I.
    100125 mg/dl126 mg/dl
    2 hour plasma glucose after ingestion of a 75g glucose load140 199 mg/dl200 mg/dl
    5.76.4% 6.5%

    There is no direct evidence from a randomized controlled trial on the cost-effectiveness of screening. However, economic modeling studies have suggested that targeted opportunistic screening for prediabetes and/or type 2 diabetes would be cost effective. In addition, there is robust evidence on the beneficial effects of early treatment of prediabetes, and similar evidence is accumulating on early treatment for undiagnosed diabetes. There is therefore a strong rationale for undertaking screening for prediabetes and undiagnosed diabetes among high-risk people in clinical settings.


    Scope of the problem burden of hyperglycemia

    The global prevalence of impaired glucose tolerance among adults was 6.4% in 2011, and is projected to increase to 7.1% by 2030. Almost 30% of adult Americans have prediabetes, and over 40% have hyperglycemia of any kind, i.e. prediabetes or diabetes. Compared to patients with normoglycemia, those with prediabetes have an 8%-60% increased mortality, a 20% increase in macrovascular disease, and an increased risk of microvascular complications, including retinopathy neuropathy , and chronic kidney disease .

    Identifiable preclinical phases

    Which Tests Help My Health Care Professional Know What Kind Of Diabetes I Have

    Accuracy of prediabetes screening tests is low

    Even though the tests described here can confirm that you have diabetes, they cant identify what type you have. Sometimes health care professionals are unsure if diabetes is type 1 or type 2. A rare type of diabetes that can occur in babies, called monogenic diabetes, can also be mistaken for type 1 diabetes. Treatment depends on the type of diabetes, so knowing which type you have is important.

    To find out if your diabetes is type 1, your health care professional may look for certain autoantibodies. Autoantibodies are antibodies that mistakenly attack your healthy tissues and cells. The presence of one or more of several types of autoantibodies specific to diabetes is common in type 1 diabetes, but not in type 2 or monogenic diabetes. A health care professional will have to draw your blood for this test.

    If you had diabetes while you were pregnant, you should get tested no later than 12 weeks after your baby is born to see if you have type 2 diabetes.

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